Transcriptomic analysis of enteropathy in Zambian children with severe acute malnutrition

Possible Risk Factors Related to Malnutrition in 6-59-Month Children with Severe Acute Malnutrition in District Pakpattan, Punjab

Background: Malnutrition is responsible for one third of the mortality rate among children less than 5 years old. Worldwide, 54% of the child deaths are due to malnutrition and the caseload in Pakistan is equal to 46%. In the current study, we attempted to identify the possible risk factors related to malnutrition among6-59-month children in Pakpattan, Punjab province. Methods: A total of 500 s...

Management of severe acute malnutrition in children.

Severe acute malnutrition (SAM) is defined as a weight-for-height measurement of 70% or less below the median, or three SD or more below the mean National Centre for Health Statistics reference values, the presence of bilateral pitting oedema of nutritional origin, or a mid-upper-arm circumference of less than 110 mm in children age 1-5 years. 13 million children under age 5 years have SAM, and...

Undernutrition and severe acute malnutrition in children

Characterizing the metabolic phenotype of intestinal villus blunting in Zambian children with severe acute malnutrition and persistent diarrhea

BACKGROUND Environmental enteric dysfunction (EED) is widespread throughout the tropics and in children is associated with stunting and other adverse health outcomes. One of the hallmarks of EED is villus damage. In children with severe acute malnutrition (SAM) the severity of enteropathy is greater and short term mortality is high, but the metabolic consequences of enteropathy are unknown. Her...

Amoxicillin for Severe Acute Malnutrition in Children.

n engl j med 375;2 nejm.org July 14, 2016 190 with HIV. However, granulomatous reactions, lymphocytic infiltration, and elevated levels of CSF proinflammatory cytokines have been described.1,2 The degree of inflammation in patients who are receiving HAART is unknown but is probably higher than in patients who are not receiving HAART. Our trial was designed to aid decision making at the point of...